Recent research reported improvements in aggression, disruptiveness, self injury, stereotypy and social withdrawal in children with Down's Syndrome with autism and severe intellectual disability (mean age 7.8 years old) following the use of Risperidone.  Weight gain was a reported side effect.

Reference:  Capone, George T. MD  Goyal, Parag BA ; Grados, Marco MD, MPH; Smith, Brandon MD; Kammann, Heather BA  (2008) Risperidone Use in Children with Down Syndrome, Severe Intellectual Disability, and Comorbid Autistic Spectrum Disorders: A Naturalistic Study.   Journal of Developmental & Behavioral Pediatrics. 29(2):106-116

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